Gravibinan Injection Uses
About Gravibinan Injection
Gravibinan injection is a hormonal medicine combining a progestin (Hydroxyprogesterone Caproate) and an estrogen (Estradiol Valerate). It is used under the direction of a physician for specific women’s health conditions, particularly in pregnancy‑related situations.
Gravibinan Injection Uses
Gravibinan injection is commonly used for:
- Prevention of pre‑term birth in women with a history of early delivery.
- Management of threatened miscarriage and other pregnancy‑related issues where hormonal support is required.
- Treatment of certain gynecological disorders involving estrogen‑progestin therapy.
Gravibinan Injection Dosage and Administration
Always use the medicine exactly as directed by your doctor:
Typical Dosage:
- Injection administered intramuscularly (IM) or as advised by your doctor.
- Mostly initiated in pregnant women with risk of pre‑term birth.
- Take once weekly from about 16 weeks gestation up to week 36 or delivery, whichever is first.
- The exact dose and schedule will depend on your obstetrician’s plan.
How to take:
- It should be administered by or under supervision of a qualified healthcare professional.
- Do not self‑inject unless instructed and trained by your doctor.
- If you miss a scheduled injection, contact your doctor immediately for guidance (do not simply double the next dose).
Gravibinan Injection Warnings
Do not use gravibinan injection if you:
- Are allergic to Hydroxyprogesterone Caproate, Estradiol Valerate, or any component of the formulation.
- Have a history of thrombosis or thromboembolic disorders.
- Have known or suspected breast cancer, estrogen‑dependent tumour, or undiagnosed vaginal bleeding.
- Have severe liver disease.
- Have active malignant disease of the liver.
- Are in a situation where the benefit does not outweigh the risk as judged by your physician.
Gravibinan Injection Precautions
Talk with your doctor first if you:
- Have a history of heart problems.
- Have a history of stroke or high blood pressure.
- Have a history of asthma.
- Have liver or kidney disease.
- Have a history of migraine headaches.
- Have a history of depression or mood disorders.
- Are taking any other hormonal medicines, blood thinners, or medications that affect clotting.
Also, remember:
- Hormonal combination therapies may increase the risk of blood clots, stroke or heart attack, particularly if other risk factors (smoking, obesity) are present.
- Always inform your doctor of your full medical history and all medicines you take.
Gravibinan Injection Side Effects
Most people tolerate the gravibinan injection under medical supervision, but some may experience:
- Pain
- Redness or swelling at the injection site.
- Nausea
- Vomiting
- Headache
- Dizziness
- Breast tenderness
- Changes in appetite or weight
- Mood changes
- Fatigue
Rare but serious side effects may include:
- Signs of clotting
- Leg pain
- leg swelling
- Sudden chest pain
- Shortness of breath
- Yellowing of skin/eyes
- Severe allergic reaction
Storage Instructions
- Keep the medicine in its original packaging.
- Store at room temperature.
- Keep away from direct sunlight and moisture.
- Protect from extreme heat.
- Keep out of reach of children.
Packaging and Quantity
Gravibinan Injection is available in ampoules (2 ml) in boxes (1 ampoule per box) in Pakistan.
Prescription Requirement
A doctor’s prescription is required for gravibinan injection in Pakistan.
Get Expert Advice on Marham Before Using Any Medicine
Marham helps you connect with qualified doctors for expert medical advice. You can easily book online or in‑person appointments through the Marham website, mobile apps, or by calling 0311‑1222398.
Frequently Asked Questions about Gravibinan Injection
Disclaimer
Marham shares expert‑reviewed information to support your health journey. The information on this page is only to guide and inform you. For any personal advice, it’s always best to check with a medical professional.