Talk to Gastroenterologist on Ulcerative Colitis

Patient Medical History – Ulcerative Colitis

Name: Khalil Ahmad Age: 29 years Diagnosis: Ulcerative Colitis – Diagnosed in August 2024

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Treatment History & Response:

1. Prednisolone (Steroids):

On steroids continuously since diagnosis.

High doses (50–60 mg/day) were effective in controlling symptoms.

Low doses (<30 mg/day) are ineffective, and symptoms return immediately.

2. Infliximab (IV Infusion):

Received 3 induction infusions.

No significant clinical improvement observed.

3. Mesalazine (1g twice daily) + Steroids:

Tried combination therapy.

No improvement in symptoms.

4. Upadacitinib (JAK inhibitor):

Trial started.

No clinical response.

5. Current Plan:

My doctors have now decided to start Mirikizumab (IL-23 inhibitor) as the next line of biological therapy.

I am awaiting my first dose.

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Current Condition & Ongoing Symptoms:

Persistent active disease with high symptom burden.

Stool frequency: More than 20 bowel movements per day, including