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Rhabdoid Tumor - Symptoms, Causes and Prevention

Rhabdoid Tumor in Urdu

یہ ایک شدت سے پھلینے والا ٹیومر ہے جو کہ گردے، جگر اور دیگر سافٹ ٹشو عالے اعضا کو متاثر کر سکتا ہے۔ یہ بیماری زیادہ تر شیر خوارگی یا بچپن میں ہی متاثر کرتی ہے۔ یہ ایک خاص جینیاتی تبدیلی کی وجہ سے لاحق ہونے والی بیماری ہے

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Summary about Rhabdoid Tumor in English

The rhabdoid tumor (RT) is an aggressive soft tissue sarcoma of the child that develops in the kidneys, the liver, the peripheral nerves and all the soft parts of the body. RT, which affects the central nervous system (CNS), is referred to as an atypical teratoid rhabdoid tumor. The rhabdoid tumor usually occurs in infancy or childhood. In most cases, the first symptoms are related to the pressure of a voluminous tumor (such as shortness of breath, abdominal muscles, peripheral nerve paralysis). In about 90% of cases, this is caused by a mutation in the SMARCB1 gene, which is a tumor suppressor gene. In rare cases, this may be due to a mutation of the SMARCA4 gene. There is no standard care for RT, although many studies are in progress. 

In addition, 10 to 15% of patients with malignant rhabdoid tumors suffer from brain tumors. Nausea is a strong feeling of discomfort in the upper part of the stomach with a strong urge to vomit. It may happen without vomiting. It is a non-specific symptom which caused by many reasons including motion sickness, dizziness, migraine, fainting, low level of blood sugar, food poisoning, anxiety, depression, pregnancy, or medication. Treatment includes tumor resection, chemotherapy, and radiation therapy. Since atypical rhabdoid teratoid tumors and renal rhabdoid tumors have the same genetic mutation and similar biopsy results, they are now considered to be identical or closely related entities.