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Systemic Sclerosis - Symptoms, Causes and Prevention

Systemic Sclerosis in Urdu

سسٹیمک سکلیروسیس ان بیماریوں میں شمار کی جاتی ہے جن کا ابھی تک کوئی واضح علاج اور وجہ دریافت نہیں کی جا سکی ہے۔ یہ بیماری بہت کم لوگوں کو متاثر کرتی ہے اور اس کی علامات جلد، جوڑوں، اور اندرونی اعضا جیسے کہ دل، گردوں، نظام انہضام کو مٹاثر کر سکتی ہیں۔ اس بیماری کا علاج مشکل ہے یہی وجہ ہے کہ علاج کا مقصد اس کی پیچیدگیوں کو مزید بڑھنے سے روکنے پر نظر آتا ہے۔ یہ بیماری بچوں میں بیت کم نظر آتی ہے جب کہ بڑی عمر میں جوکے افراد جو کہ بیس سے پچاس کے پیٹے میں ہوں اس کی شرح زیادہ ہے۔ 

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Summary about Systemic Sclerosis in English

Systemic sclerosis is one of the rare diseases that have no specific cause pointed to date. It is identified by conditions like vascular abnormalities and diffuse fibrosis. Vascular symptoms are related to organs like skin, joints, heart, GI tract, and kidneys. It is diagnosed by clinical investigations and some lab tests are ordered to aid prognosis. Treating this disease is difficult that is why treatment is mostly focused on the better management of complications. Patients with SSc need team care for their treatment and have to consult a rheumatologist with experience of treating this condition. 

Symptoms of Systemic Sclerosis

Following are the symptoms of systemic sclerosis:

  • Raynaud's phenomenon 
  • Thickening of skin
  • Swelling of distal extremities 
  • Polyarthralgia 
  • GI disorders
  • Respiratory problems
  • Cardiac arrhythmias
  • Pericarditis 
  • Scleroderma renal crisis 

Causes of Systemic Sclerosis

It is an autoimmune disorder with pathogenesis being poorly understood do far. Certain factors are recognized to initiate the disease which can environmental, social, and physical in nature. These lead to vascular changes, immune alterations, and excessive production of collagen that lead to manifestations of SSc. It mostly affects women counting for as much as 75% of total SSc cases reported. 

Types of Systemic Sclerosis

Systemic sclerosis is classified into the following categories:
Limited systemic sclerosis: In this type, patients suffer from skin tightening at elbows, knees, and face. The presence of pulmonary hypertension and GERD further aggravate symptoms.

Generalized systemic sclerosis: There is extensive involvement of skin-related symptoms along with Raynaud's syndrome, GI problems, interstitial lung disease, and scleroderma renal crisis. 

Systemic sclerosis sine scleroderma:  In this type of SSc there ae no skin-related symptoms but patients have SSC antibodies and visceral manifestations.